Yes there is Will (Y). The bearings have to be smaller due to the larger axle, and so they can die quite quickly. The cranks are also way easier to round as a number of people have explained in this thread :D. As I have said before the only reason to go to ISIS is if you want strong axles. Snapping axles is not a nice experience and can easily lead to a lot of pain. Though you may find it is cheaper to replace a normal bb every 6 months or so for £12, than to replace an ISIS BB for £30+ when the bearings die (which could be well under 6 months if you are a hard rider).