its not ideal but it can quite easily be built up, i work in a bike shop and wheel building is my speciality! as long as you leave the spaces in the hub flange on one side opposite eachother and on the other side the spaces at 90degrees to but still opposite eachother, then the wheel should be reasonably ok. The only thing i can see being a problem is that the tension and length of the spokes wont all be perfectly even, so you might find yourself having to true the wheel slightly more regularly! if you build the wheel yourself just make sure the spoke tension is as even as possible, or get the wheel profesionally built and it should be fine!