As long as the drive path (d, e, f what ever) doesn't change you'll be fine with running your tunes through itunes, i do it, on a normal usb EHD and it's fine, just hope/make sure you don't let the drive path change, or it'll gay your whole list thing. I also have most of my stuff on it (apart from installed things, program files etc) but yeah, it's all good, not a problem with speed or anything. I have a 250gb Elements one from argos, 75 quid i think it was a need to buy kinda thing as my mum raped my comp and i needed to back up everything asap, didn't bother looking around.